3‐Hydroxyacyl‐CoA epimerase is a peroxisomal enzyme and therefore not involved in mitochondrial fatty acid oxidation

FEBS Letters

Chu, Chin-hung¹  Schulz, Horst¹ 

[1] Department of Chemistry, The City College of the City University of New York, New York, NY 10031, USA

关键词: Rat liver;    3-Hydroxyacyl-CoA epimerase;    Subcellular location;    Mitochondria;    Peroxisome;    β-Oxidation;    Polyunsaturated fatty acid;    Mops;    3-(N-morpholino)propanesulfonic acid;   

DOI  :  10.1016/0014-5793(85)80755-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The subcellular location of 3-hydroxyacyl-CoA epimerase (EC 5.1.2.3) was studied by differential centrifugation and Percoll density gradient centrifugation of a rat liver homogenate. The enzyme was found to be associated with peroxisomes but not with mitochondria. This observation proves that 3-hydroxy-acyl-CoA epimerase does not function in mitochondrial β-oxidation ofpolyunsaturated fatty acids which are degraded by a modified pathway.

【 授权许可】

Unknown