ARF tumor suppression in the nucleouls

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Maggi, Leonard B., Jr.¹  Winkeler, Crystal L.¹  Miceli, Alexander P.¹  Apicelli, Anthony J.¹  Brady, Suzanne N.¹  Kuchenreuther, Michael J.¹  Weber, Jason D.¹ 

[1] Washington Univ, Sch Med, Siteman Canc Ctr, BRIGHT Inst,Dept Internal Med,Div Mol Oncol, St Louis, MO 63110 USA

关键词: ARF;    Nucleolus;    Ribosome;    Cell cycle;    p53;   

DOI  :  10.1016/j.bbadis.2014.01.016

来源: Elsevier

【 摘 要 】

Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARFs basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free