Inflammation, demyelination, and degeneration - Recent insights from MS pathology

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1812

Review

Stadelmann, Christine¹  Wegner, Christiane¹  Brueck, Wolfgang¹ 

[1] Univ Med Ctr, Inst Neuropathol, D-37099 Gottingen, Germany

关键词: Multiple sclerosis;    Pathogenesis;    Pathology;    Neuroaxonal damage;    Autoimmunity;    Progressive disease;   

DOI  :  10.1016/j.bbadis.2010.07.007

来源: Elsevier

【 摘 要 】

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which responds to anti-inflammatory treatments in the early disease phase. However, the pathogenesis of the progressive disease phase is less well understood, and inflammatory as well as neurodegenerative mechanisms of tissue damage are currently being discussed. This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free