Novel aspects on the pathogenesis of Mycoplasma pneumoniae pneumonia and therapeutic implications

Frontiers in Microbiology

Hirokazu eKimura¹  Kazuhide eNakagaki²  Shoichi eNiwa³  Hiroyuki eTsukagoshi³  Hajime eTakizawa³  Yoshiko eSasaki³  Daisuke eKurai⁴  Haruyuki eIshii⁴  Susumu eHirao⁴  Hiroki eNunokawa⁴  Hiroo eWada⁴  Hajime eGoto⁴  Naoki eTsujimoto⁴  Takeshi eSaraya⁴  Kosuke eOhkuma⁴  Kunihisa eKozawa⁵  Koh eNakata⁶ 

[1] Dental Hospital;College of Veterinary Medicine, Nippon Veterinary and Life Science University;Gunma Prefectural Institute of Public Health and Environmental Sciences;Kyorin University School of Medicine;National Institute of Infectious Diseases;;Niigata University Medical &

关键词: Epidemiology;    Pathology;    Animal Models;    Pathogenesis;    Mycoplasma pneumoniae pneumonia;   

DOI  :  10.3389/fmicb.2014.00410

来源: DOAJ

【 摘 要 】

Mycoplasma pneumoniae (Mp) is a leading cause of community acquired pneumonia. Knowledge regarding Mp pneumonia obtained from animal models or human subjects has been discussed in many different reports. Accumulated expertise concerning this critical issue has been hard to apply clinically, and potential problems may remain undiscovered. Therefore, our multidisciplinary team extensively reviewed the literature regarding Mp pneumonia, and compared findings from animal models with those from human subjects. In human beings, the characteristic pathological features of Mp pneumonia have been reported as alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area. Herein, we demonstrated the novel aspects of Mp pneumonia that the severity of the Mp pneumonia seemed to depend on the host innate immunity to the Mp, which might be accelerated by antecedent Mp exposure (re-exposure or latent respiratory infection) through up-regulation of Toll-like receptor 2 expression on bronchial epithelial cells and alveolar macrophages. The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. This exhaustive review focuses on pathogenesis and extends to some therapeutic implications such as clarithromycin, and discusses the various diverse aspects of Mp pneumonia. It is our hope that this might lead to new insights into this common respiratory disease.

【 授权许可】

Unknown