A Tamao-Fleming oxidation route to dipeptides bearing N,O-acetal functionality

TETRAHEDRON LETTERS

卷:58

Article

Ibrahim, Sherif M. S.¹  Banerjee, Koushik¹  Slater, Kara A.¹  Friestad, Gregory K.¹ 

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

关键词: Peptides;    Oxidation reactions;    N,O-Acetals;    Prodrugs;    Bioconjugate chemistry;   

DOI  :  10.1016/j.tetlet.2017.11.036

来源: Elsevier

【 摘 要 】

Tamao-Fleming oxidation of the N-dimethylphenylsilylmethyl group linked to the nitrogen of a peptide bond enables access to dipeptide N,O-acetal functionality. The N-silylmethyl functionality serves as a latent form of the N,O-acetal which is revealed after peptide bond construction. (C) 2017 Published by Elsevier Ltd.

【 授权许可】

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