The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases

Frontiers in Physiology

Physiology

Yanling Wu¹  Jieqiong Shen¹  Ruiyi Lin¹  Taimin Xiong¹  Hongbing Song¹  Jing Wang¹  Xiaohan Zhang¹  Weimin Lin²  Tianfang Xiao³ 

[1] College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, Fujian, China;null;[e-mail];

关键词: adipocyte;    adipose tissue;    mitochondria;    obesity;    metabolic syndrome;   

DOI  :  10.3389/fphys.2023.1261204

 received in 2023-07-19, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Adipose tissue is the most important energy storage organ in the body, maintaining its normal energy metabolism function and playing a vital role in keeping the energy balance of the body to avoid the harm caused by obesity and a series of related diseases resulting from abnormal energy metabolism. The dysfunction of adipose tissue is closely related to the occurrence of diseases related to obesity metabolism. Among various organelles, mitochondria are the main site of energy metabolism, and mitochondria maintain their quality through autophagy, biogenesis, transfer, and dynamics, which play an important role in maintaining metabolic homeostasis of adipocytes. On the other hand, mitochondria have mitochondrial genomes which are vulnerable to damage due to the lack of protective structures and their proximity to sites of reactive oxygen species generation, thus affecting mitochondrial function. Notably, mitochondria are closely related to other organelles in adipocytes, such as lipid droplets and the endoplasmic reticulum, which enhances the function of mitochondria and other organelles and regulates energy metabolism processes, thus reducing the occurrence of obesity-related diseases. This article introduces the structure and quality control of mitochondria in adipocytes and their interactions with other organelles in adipocytes, aiming to provide a new perspective on the regulation of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases, and to provide theoretical reference for further revealing the molecular mechanism of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases.

【 授权许可】

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Copyright © 2023 Song, Zhang, Wang, Wu, Xiong, Shen, Lin, Xiao and Lin.