Adipose tissue expansion in obesity, health, and disease

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Ursula White¹ 

[1] null;

关键词: adipose tissue;    adipose expansion;    adipocyte;    adipogenesis;    obesity;    human;    metabolic health;   

DOI  :  10.3389/fcell.2023.1188844

 received in 2023-03-17, accepted in 2023-04-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

White adipose tissue (WAT) expands under physiological conditions via an increase in adipocyte size (hypertrophy) and/or number (hyperplasia; adipogenesis), and the ability of WAT to expand to accommodate energy demands is a significant determinant of metabolic health status. Obesity is associated with impaired WAT expansion and remodeling, which results in the deposition of lipids to other non-adipose organs, leading to metabolic derangements. Although increased hyperplasia has been implicated as a cornerstone in promoting healthy WAT expansion, recent developments suggest that the role of adipogenesis as a contributing factor in the transition from impaired subcutaneous WAT expansion to impaired metabolic health remains up for debate. This mini-review will summarize recent developments and highlight emerging concepts on the features of WAT expansion and turnover, and the significance in obesity, health, and disease.

【 授权许可】

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Copyright © 2023 White.