期刊论文

【摘要】

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction. They regulate key signaling pathways known to be critically involved in tumor progression. Recent results point to an altered expression or activity of different CK1 isoforms in tumor cells. This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis.

【授权许可】

CC BY
© Schittek and Sinnberg; licensee BioMed Central Ltd. 2014

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Molecular Cancer
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
Review
Tobias Sinnberg¹ Birgit Schittek¹
[1] Department of Dermatology, Division of Dermatooncology, University of Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Germany;
关键词: Casein kinase 1; Tumor; Cancer; Melanoma; β-catenin; p53;
DOI : 10.1186/1476-4598-13-231
received in 2014-05-16, accepted in 2014-09-26, 发布年份 2014
来源: Springer
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