Macrophage’s role in solid tumors: two edges of a sword

Cancer Cell International

Research

Zahra payandeh¹  Rajan Kumar Pandey¹  Mohsen Nabi Afjadi²  Nogol Ghalamkarpour³  Maryam Zokaei⁴  Maryam Noei-Khesht Masjedi⁵  Roben Soheili⁶  Ardavan Ahmadvand⁷  Yeganeh Eslami⁸  Mina Fatehnejad⁹  Mahsa Yarizadeh^1,10  Romina Jahandideh^1,11  Arian Jahandideh^1,12 

[1] Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden;Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran;Department of Clinical Laboratory Sciences, School of Allied Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran;Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran;Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Islamic Azad University, Tehran Medical Branch, Tehran, Iran;Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran;Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran;Usern Office, Mazandaran University of Medical Sciences, Sari, Iran;

关键词: Cancer;    Macrophage;    Glioma;    Melanoma;    Tumor;   

DOI  :  10.1186/s12935-023-02999-3

 received in 2023-04-09, accepted in 2023-07-24,  发布年份 2023

来源: Springer

【 摘 要 】

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis, extracellular matrix reconfiguration, cellular proliferation, metastasis, and immunosuppression. They further exhibit resilience to chemotherapy and immunotherapy via meticulous checkpoint blockades. When appropriately stimulated, macrophages can morph into a potent bidirectional component of the immune system, engulfing malignant cells and annihilating them with cytotoxic substances, thus rendering them intriguing candidates for therapeutic targets. As myelomonocytic cells relentlessly amass within tumor tissues, macrophages rise as prime contenders for cell therapy upon the development of chimeric antigen receptor effector cells. Given the significant incidence of macrophage infiltration correlated with an unfavorable prognosis and heightened resistance to chemotherapy in solid tumors, we delve into the intricate role of macrophages in cancer propagation and their promising potential in confronting four formidable cancer variants—namely, melanoma, colon, glioma, and breast cancers.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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