Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Daniel Rueckert¹  Timothy J. Dawes²  Declan P. O’Regan²  Antonio de Marvao²  Ben Corden²  Wenzhe Shi³  Stuart A. Cook⁴ 

[1] Department of Computing, Imperial College London, South Kensington Campus, London, UK;Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK;Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK;Department of Computing, Imperial College London, South Kensington Campus, London, UK;Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK;National Heart Centre Singapore, Singapore and Duke-NUS Graduate Medical School, Singapore, Singapore;

关键词: Obesity;    Body composition;    Cardiovascular magnetic resonance;    Cardiac remodelling;    Cardiac atlas;   

DOI  :  10.1186/s12968-016-0251-4

 received in 2016-03-09, accepted in 2016-05-18,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAlthough obesity is associated with alterations in left ventricular (LV) mass and volume which are of prognostic significance, widely differing patterns of remodelling have been attributed to adiposity. Our aim was to define the relationship between body composition and LV geometry using three-dimensional cardiovascular magnetic resonance.MethodsIn an observational study 1530 volunteers (55 % female, mean age 41.3 years) without known cardiovascular disease underwent investigation including breath-hold high spatial resolution 3D cines. Atlas-based segmentation and co-registration was used to create a statistical model of wall thickness (WT) and relative wall thickness (RWT) throughout the LV. The relationship between bio-impedence body composition and LV geometry was assessed using 3D regression models adjusted for age, systolic blood pressure (BP), gender, race and height, with correction to control the false discovery rate.ResultsLV mass was positively associated with fat mass in women but not in men (LV mass: women β = 0.11, p < 0.0001; men β = −0.01, p = 0.82). The 3D models revealed that in males fat mass was strongly associated with a concentric increase in relative wall thickness (RWT) throughout most of the LV (β = 0.37, significant area = 96 %) and a reduced mid-ventricular cavity (β = −0.22, significant area = 91 %). In women the regional concentric hypertrophic association was weaker, and the basal lateral wall showed an inverse relationship between RWT and fat mass (β = −0.11, significant area = 4.8 %).ConclusionsIn an adult population without known cardiovascular disease increasing body fat is predominately associated with asymmetric concentric hypertrophy independent of systolic BP, with women demonstrating greater cavity dilatation than men. Conventional mass and volume measurements underestimate the impact of body composition on LV structure due to anatomic variation in remodelling.

【 授权许可】

CC BY   
© The Author(s). 2016