Cardiac steatosis and left ventricular function in men with metabolic syndrome

Journal of Cardiovascular Magnetic Resonance

Research

Reijo Sirén¹  Kirsi Lauerma²  Jesper Lundbom³  Antti Hakkarainen³  Nina Lundbom³  Kristofer Nyman³  Marja-Riitta Taskinen⁴  Markku S Nieminen⁴  Marit Granér⁴  Markku O Pentikäinen⁴ 

[1] Department of General Practice and Primary Health Care, Health Care Centre of City of Helsinki and University of Helsinki, Helsinki, Finland;Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, BOX 281, Stenbäckinkatu 11, FI-00029, Helsinki, HUS, Finland;Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, BOX 340, Haartmaninkatu 4, FI-00029, HUS, Finland;Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland;

关键词: Cardiovascular magnetic resonance;    Proton magnetic resonance spectroscopy;    Metabolic syndrome;    Obesity;    Diastolic dysfunction;    Myocardial triglyceride content;    Epicardial fat;    Pericardial fat;    Cardiac steatosis;   

DOI  :  10.1186/1532-429X-15-103

 received in 2013-05-22, accepted in 2013-11-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundEctopic accumulation of fat accompanies visceral obesity with detrimental effects. Lipid oversupply to cardiomyocytes leads to cardiac steatosis, and in animal studies lipotoxicity has been associated with impaired left ventricular (LV) function. In humans, studies have yielded inconclusive results. The aim of the study was to evaluate the role of epicardial, pericardial and myocardial fat depots on LV structure and function in male subjects with metabolic syndrome (MetS).MethodsA study population of 37 men with MetS and 38 men without MetS underwent cardiovascular magnetic resonance and proton magnetic spectroscopy at 1.5 T to assess LV function, epicardial and pericardial fat area and myocardial triglyceride (TG) content.ResultsAll three fat deposits were greater in the MetS than in the control group (p <0.001). LV diastolic dysfunction was associated with MetS as measured by absolute (471 mL/s vs. 667 mL/s, p = 0.002) and normalized (3.37 s-1 vs. 3.75 s-1, p = 0.02) LV early diastolic peak filling rate and the ratio of early diastole (68% vs. 78%, p = 0.001). The amount of epicardial and pericardial fat correlated inversely with LV diastolic function. However, myocardial TG content was not independently associated with LV diastolic dysfunction.ConclusionsIn MetS, accumulation of epicardial and pericardial fat is linked to the severity of structural and functional alterations of the heart. The role of increased intramyocardial TG in MetS is more complex and merits further study.

【 授权许可】

Unknown   
© Nyman et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.