Observational study of regional aortic size referenced to body size: production of a cardiovascular magnetic resonance nomogram

Journal of Cardiovascular Magnetic Resonance

Oliver J Rider²  Stefan Neubauer²  Tim Donovan³  Paul Leeson⁴  Saul G Myerson²  Jane M Francis²  Alex Pitcher²  Richard Nethononda²  Rajarshi Banerjee²  Ntobeko AB Ntusi²  Cameron J Holloway¹  Adam J Lewandowski⁴  Anne E Davis² 

[1] St. Vincent’s Hospital and the Victor Chang Cardiac Research Institute, Sydney, Australia;Radcliffe Department of Medicine, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK;University of Cumbria Health and Medical Sciences, Lancaster, UK;Oxford Clinical Cardiovascular Research Facility, University of Oxford, Oxford, UK

关键词: Normal Range;    Obesity;    Cardiovascular magnetic resonance;    Aorta;   

Others  :  801884
DOI  :  10.1186/1532-429X-16-9

 received in 2013-07-19, accepted in 2014-01-14,  发布年份 2014

【 摘 要 】

Background

Cardiovascular magnetic resonance (CMR) is regarded as the gold standard for clinical assessment of the aorta, but normal dimensions are usually referenced to echocardiographic and computed tomography data and no large CMR normal reference range exists. As a result we aimed to 1) produce a normal CMR reference range of aortic diameters and 2) investigate the relationship between regional aortic size and body surface area (BSA) in a large group of healthy subjects with no vascular risk factors.

Methods

447 subjects (208 male, aged 19–70 years) without identifiable cardiac risk factors (BMI range 15.7–52.6 kg/m²) underwent CMR at 1.5 T to determine aortic diameter at three levels: the ascending aorta (Ao) and proximal descending aorta (PDA) at the level of the pulmonary artery, and the abdominal aorta (DDA), at a level 12 cm distal to the PDA. In addition, 201 of these subjects had aortic root imaging, allowing for measurements at the level of the aortic valve annulus (AV), aortic sinuses and sinotubular junction (STJ).

Results

Normal diameters (mean ±2 SD) were; AV annulus male(♂) 24.4 ± 5.4, female (♀) 21.0 ± 3.6 mm, aortic sinus♂32.4 ± 7.7, ♀27.6 ± 5.8 mm, ST-junction ♂25.0 ± 7.4, ♀21.8 ± 5.4 mm, Ao ♂26.7 ± 7.7, ♀25.5 ± 7.4 mm, PDA ♂20.6 ± 5.6, +18.9 ± 4.0 mm, DDA ♂17.6 ± 5.1, ♀16.4 ± 4.0 mm. Aortic root and thoracic aortic diameters increased at all levels measured with BSA. No gender difference was seen in the degree of dilatation with increasing BSA (p > 0.5 for all analyses).

Conclusion

Across both genders, increasing body size is characterized by a modest degree of aortic dilatation, even in the absence of traditional cardiovascular risk factors.

【 授权许可】

   
2014 Davis et al.; licensee BioMed Central Ltd.

【 图 表 】

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