HIV is an independent predictor of aortic stiffness

Journal of Cardiovascular Magnetic Resonance

Research

Ntobeko Ntusi¹  Alex Pitcher¹  Stefan Neubauer²  Rajarshi Banerjee³  Kieran Clarke³  Mina Asaad⁴  Oliver J Rider⁴  Cameron J Holloway⁵  Gemma Hancock⁶  Genevieve Clutton⁶  Lucy Dorrell⁶  Emma Wainwright⁶  Katherine Samaras⁷ 

[1] Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, (OCMR), John Radcliffe Hospital, OX3 9DU, Oxford, UK;Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, (OCMR), John Radcliffe Hospital, OX3 9DU, Oxford, UK;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK;Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford, UK;Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford, UK;Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, (OCMR), John Radcliffe Hospital, OX3 9DU, Oxford, UK;Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford, UK;Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, (OCMR), John Radcliffe Hospital, OX3 9DU, Oxford, UK;St Vincent’s Hospital, Sydney, Australia;Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK;St Vincent’s Hospital, Sydney, Australia;

关键词: Aorta;    Cardiovascular magnetic resonance;    HIV;   

DOI  :  10.1186/s12968-014-0057-1

 received in 2014-03-28, accepted in 2014-07-16,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPatients with treated Human Immunodeficiency Virus-1 (HIV) infection are at increased risk of cardiovascular events. Traditionally much of this risk has been attributed to metabolic and anthropometric abnormalities associated with HIV, which are similar to the metabolic syndrome (MS), an established risk factor for cardiovascular mortality. It remains unclear whether treated HIV infection is itself associated with increased risk, via increase vascular stiffness.Methods226 subjects (90 with HIV) were divided into 4 groups based on HIV and MS status: 1) HIV-ve/MS-ve, 2) HIV-ve/MS + ve, 3) HIV + ve/MS-ve and 4)HIV + ve/MS + ve. CMR was used to determine aortic pulse wave velocity (PWV) and regional aortic distensibility (AD).ResultsPWV was 11% higher and regional AD up to 14% lower in the HIV + ve/MS-ve group when compared to HIV-ve/MS-ve (p < 0.01 all analyses). PWV and AD in the HIV + ve/MS-ve group was similar to that observed in the HIV-ve/MS + ve group (p > 0.99 all analyses). The HIV + ve/MS + ve group had 32% higher PWV and 30-34% lower AD than the HIV-ve/MS-ve group (all p < 0.001), and 19% higher PWV and up to 31% lower AD than HIV + ve/MS-ve subjects (all p < 0.05). On multivariable regression, age, systolic blood pressure and treated HIV infection were all independent predictors of both PWV and regional AD.ConclusionAcross multiple measures, treated HIV infection is associated with increased aortic stiffness and is also an independent predictor of both PWV and regional AD. The magnitude of the effect of treated HIV and MS are similar, with additive detrimental effects on central vascular elasticity.

【 授权许可】

CC BY   
© Rider et al.; licensee BioMed Central 2014