Observational study of regional aortic size referenced to body size: production of a cardiovascular magnetic resonance nomogram

Journal of Cardiovascular Magnetic Resonance

Research

Adam J Lewandowski¹  Paul Leeson¹  Richard Nethononda²  Rajarshi Banerjee²  Stefan Neubauer²  Saul G Myerson²  Jane M Francis²  Anne E Davis²  Alex Pitcher²  Ntobeko AB Ntusi²  Oliver J Rider²  Cameron J Holloway³  Tim Donovan⁴ 

[1] Oxford Clinical Cardiovascular Research Facility, University of Oxford, Oxford, UK;Radcliffe Department of Medicine, Division of Cardiovascular Medicine, John Radcliffe Hospital, OX3 9DU, Oxford, UK;St. Vincent’s Hospital and the Victor Chang Cardiac Research Institute, Sydney, Australia;University of Cumbria Health and Medical Sciences, Lancaster, UK;

关键词: Aorta;    Cardiovascular magnetic resonance;    Obesity;    Normal Range;   

DOI  :  10.1186/1532-429X-16-9

 received in 2013-07-19, accepted in 2014-01-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCardiovascular magnetic resonance (CMR) is regarded as the gold standard for clinical assessment of the aorta, but normal dimensions are usually referenced to echocardiographic and computed tomography data and no large CMR normal reference range exists. As a result we aimed to 1) produce a normal CMR reference range of aortic diameters and 2) investigate the relationship between regional aortic size and body surface area (BSA) in a large group of healthy subjects with no vascular risk factors.Methods447 subjects (208 male, aged 19–70 years) without identifiable cardiac risk factors (BMI range 15.7–52.6 kg/m2) underwent CMR at 1.5 T to determine aortic diameter at three levels: the ascending aorta (Ao) and proximal descending aorta (PDA) at the level of the pulmonary artery, and the abdominal aorta (DDA), at a level 12 cm distal to the PDA. In addition, 201 of these subjects had aortic root imaging, allowing for measurements at the level of the aortic valve annulus (AV), aortic sinuses and sinotubular junction (STJ).ResultsNormal diameters (mean ±2 SD) were; AV annulus male(♂) 24.4 ± 5.4, female (♀) 21.0 ± 3.6 mm, aortic sinus♂32.4 ± 7.7, ♀27.6 ± 5.8 mm, ST-junction ♂25.0 ± 7.4, ♀21.8 ± 5.4 mm, Ao ♂26.7 ± 7.7, ♀25.5 ± 7.4 mm, PDA ♂20.6 ± 5.6, +18.9 ± 4.0 mm, DDA ♂17.6 ± 5.1, ♀16.4 ± 4.0 mm. Aortic root and thoracic aortic diameters increased at all levels measured with BSA. No gender difference was seen in the degree of dilatation with increasing BSA (p > 0.5 for all analyses).ConclusionAcross both genders, increasing body size is characterized by a modest degree of aortic dilatation, even in the absence of traditional cardiovascular risk factors.

【 授权许可】

Unknown   
© Davis et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.