The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect

Journal of Cardiovascular Magnetic Resonance

James A Hamilton⁷  Frederick L Ruberg⁷  Caroline M Apovian¹  Megan R Ruth¹  Sherman J Bigornia¹  Michael P LaValley³  Ye Qiao⁴  Tuan Pham²  Alkystis Phinikaridou⁵  Zhongjing Chen⁶  Ning Hua⁶ 

[1] The Department of Endocrinology, Diabetes, and Nutrition, Boston University Medical Center, Boston, MA, USA;The Department of Biomedical Engineering, Boston University, Boston, MA, USA;The Department of Biostatistics, Boston University School of Medicine, Boston, MA, USA;The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, MD, USA;The Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, UK;The Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA;The Department of Radiology, Boston University School of Medicine, Boston, MA, USA

关键词: Pericardial fat;    Obesity;    Cardiovascular magnetic resonance;   

Others  :  801145
DOI  :  10.1186/1532-429X-16-37

 received in 2012-11-01, accepted in 2014-05-12,  发布年份 2014

【 摘 要 】

Background

Although increased volume of pericardial fat has been associated with decreased cardiac function, it is unclear whether this association is mediated by systemic overall obesity or direct regional fat interactions. We hypothesized that if local effects dominate, left ventricular (LV) function would be most strongly associated with pericardial fat that surrounds the left rather than the right ventricle (RV).

Methods

Female obese subjects (n = 60) had cardiovascular magnetic resonance (CMR) scans to obtain measures of LV function and pericardial fat volumes. LV function was obtained using the cine steady state free precession imaging in short axis orientation. The amount of pericardial fat was determined volumetrically by the cardiac gated T1 black blood imaging and normalized to body surface area.

Results

In this study cohort, LV fat correlated with several LV hemodynamic measurements including cardiac output (r = -0.41, p = 0.001) and stroke volume (r = -0.26, p = 0.05), as well as diastolic functional parameters including peak-early-filling rate (r = -0.38, p = 0.01), early late filling ratio (r = -0.34, p = 0.03), and time to peak-early-filling (r = 0.34, p = 0.03). These correlations remained significant even after adjusting for the body mass index and the blood pressure. However, similar correlations became weakened or even disappeared between RV fat and LV function. LV function was not correlated with systemic plasma factors, such as C-reactive protein (CRP), B-type natriuretic peptide (BNP), Interleukin-6 (IL-6), resistin and adiponectin (all p > 0.05).

Conclusions

LV hemodynamic and diastolic function was associated more with LV fat as compared to RV or total pericardial fat, but not with systemic inflammatory markers or adipokines. The correlations between LV function and pericardial fat remained significant even after adjusting for systemic factors. These findings suggest a site-specific influence of pericardial fat on LV function, which could imply local secretion of molecules into the underlying tissue or an anatomic effect, both mechanisms meriting future evaluation.

【 授权许可】

   
2014 Hua et al.; licensee BioMed Central Ltd.

【 图 表 】

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