The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect

Journal of Cardiovascular Magnetic Resonance

Research

Tuan Pham¹  Michael P LaValley²  Caroline M Apovian³  Sherman J Bigornia³  Megan R Ruth³  Frederick L Ruberg⁴  Ning Hua⁵  Zhongjing Chen⁵  James A Hamilton⁶  Alkystis Phinikaridou⁷  Ye Qiao⁸ 

[1] The Department of Biomedical Engineering, Boston University, Boston, MA, USA;The Department of Biostatistics, Boston University School of Medicine, Boston, MA, USA;The Department of Endocrinology, Diabetes, and Nutrition, Boston University Medical Center, Boston, MA, USA;The Department of Medicine, Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA;The Department of Radiology, Boston University School of Medicine, Boston, MA, USA;The Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA;The Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, USA;The Department of Biomedical Engineering, Boston University, Boston, MA, USA;The Department of Radiology, Boston University School of Medicine, Boston, MA, USA;The Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, UK;The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, MD, USA;

关键词: Cardiovascular magnetic resonance;    Obesity;    Pericardial fat;   

DOI  :  10.1186/1532-429X-16-37

 received in 2012-11-01, accepted in 2014-05-12,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAlthough increased volume of pericardial fat has been associated with decreased cardiac function, it is unclear whether this association is mediated by systemic overall obesity or direct regional fat interactions. We hypothesized that if local effects dominate, left ventricular (LV) function would be most strongly associated with pericardial fat that surrounds the left rather than the right ventricle (RV).MethodsFemale obese subjects (n = 60) had cardiovascular magnetic resonance (CMR) scans to obtain measures of LV function and pericardial fat volumes. LV function was obtained using the cine steady state free precession imaging in short axis orientation. The amount of pericardial fat was determined volumetrically by the cardiac gated T1 black blood imaging and normalized to body surface area.ResultsIn this study cohort, LV fat correlated with several LV hemodynamic measurements including cardiac output (r = -0.41, p = 0.001) and stroke volume (r = -0.26, p = 0.05), as well as diastolic functional parameters including peak-early-filling rate (r = -0.38, p = 0.01), early late filling ratio (r = -0.34, p = 0.03), and time to peak-early-filling (r = 0.34, p = 0.03). These correlations remained significant even after adjusting for the body mass index and the blood pressure. However, similar correlations became weakened or even disappeared between RV fat and LV function. LV function was not correlated with systemic plasma factors, such as C-reactive protein (CRP), B-type natriuretic peptide (BNP), Interleukin-6 (IL-6), resistin and adiponectin (all p > 0.05).ConclusionsLV hemodynamic and diastolic function was associated more with LV fat as compared to RV or total pericardial fat, but not with systemic inflammatory markers or adipokines. The correlations between LV function and pericardial fat remained significant even after adjusting for systemic factors. These findings suggest a site-specific influence of pericardial fat on LV function, which could imply local secretion of molecules into the underlying tissue or an anatomic effect, both mechanisms meriting future evaluation.

【 授权许可】

Unknown   
© Hua et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.