Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer

World Journal of Surgical Oncology

Case Report

Ronald R. Salem¹  Sajid A. Khan¹  Gabriella Grisotti²  Rebecca Zhu³ 

[1] Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, PO BOX 208062, New Haven, CT, USA;Department of Surgery, Yale University School of Medicine, New Haven, CT, USA;Yale University School of Medicine, New Haven, CT, USA;

关键词: Colorectal cancer;    Early onset colorectal cancer;    Locally advanced colorectal cancer;    Hereditary nonpolyposis colorectal cancer;    Lynch syndrome;    Pancreaticoduodenectomy;    Whipple procedure;   

DOI  :  10.1186/s12957-015-0755-7

 received in 2015-11-16, accepted in 2015-12-30,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3 % of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.Case presentationWe report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature.ConclusionsLocally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.

【 授权许可】

CC BY   
© Zhu et al. 2016