Oral manifestations of hereditary nonpolyposis colorectal cancer syndrome: a family case series

Journal of Medical Case Reports

Eliete Neves Silva Guerra²  Ana Carolina Acevedo²  João Batista Sousa¹  André Ferreira Leite²  Raquel Ribeiro Gomes²  Fabiana Tolentino Almeida² 

[1] Coloproctology Division, University Hospital of Brasilia, Faculty of Medicine, University of Brasilia (UNB), Brasilia, Brazil;Oral Care Center for Inherited Diseases, Division of Dentistry at University Hospital of Brasilia, Faculty of Health Sciences, University of Brasilia (UNB), Brasilia, Brazil

关键词: Hereditary nonpolyposis colorectal cancer;    Fordyce granules;    Dento-osseous anomalies;   

Others  :  1181103
DOI  :  10.1186/1752-1947-8-249

 received in 2014-03-14, accepted in 2014-05-28,  发布年份 2014

【 摘 要 】

Introduction

Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous anomalies and the second to observe Fordyce granules in a family with individuals with hereditary nonpolyposis colorectal cancer.

Case presentations

Twenty members of one Brazilian family with individuals with hereditary nonpolyposis colorectal cancer were analyzed according to the presence of colorectal cancer and the occurrence of Fordyce granules and dento-osseous anomalies. Their average age was 29.6 (range 7 to 53 years) years. Medical examinations of this family with hereditary nonpolyposis colorectal cancer were performed at the Coloproctology Division of our hospital. Then, all individuals were referred to our Oral Care Center for Inherited Diseases for intraoral examinations to verify the presence of Fordyce granules. Dental panoramic radiographs were done in order to describe dento-osseous anomalies on applying the Dental Panoramic Radiograph System. Of the 20 family members, four were diagnosed with hereditary nonpolyposis colorectal cancer and all four presented Fordyce granules in their upper lip, but only one of these four patients (Case 2) had a significant dento-osseous anomaly.

Conclusions

Our familial study verified the presence of Fordyce granules in all individuals diagnosed with hereditary nonpolyposis colorectal cancer, and the presence of significant dento-osseous anomalies in one of these cases. However, the relationship between oral manifestations and hereditary nonpolyposis colorectal cancer should be further investigated.

【 授权许可】

   
2014 Almeida et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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