Is interleukin-18 associated with polycystic ovary syndrome?

Reproductive Biology and Endocrinology

Research

Rong Li¹  Jie Qiao¹  Mei-Zhi Li¹  Yan Yang¹ 

[1] Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;

关键词: Luteinizing Hormone;    Coronary Artery Calcification;    Polycystic Ovary Syndrome;    Congenital Adrenal Hyperplasia;    PCOS Patient;   

DOI  :  10.1186/1477-7827-9-7

 received in 2010-10-25, accepted in 2011-01-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundRecent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation.MethodsTo investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured.ResultsSerum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T.ConclusionIL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.

【 授权许可】

CC BY   
© Yang et al; licensee BioMed Central Ltd. 2011