Reproductive Biology and Endocrinology | |
Is interleukin-18 associated with polycystic ovary syndrome? | |
Research | |
Rong Li1  Jie Qiao1  Mei-Zhi Li1  Yan Yang1  | |
[1] Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; | |
关键词: Luteinizing Hormone; Coronary Artery Calcification; Polycystic Ovary Syndrome; Congenital Adrenal Hyperplasia; PCOS Patient; | |
DOI : 10.1186/1477-7827-9-7 | |
received in 2010-10-25, accepted in 2011-01-18, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundRecent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation.MethodsTo investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured.ResultsSerum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T.ConclusionIL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.
【 授权许可】
CC BY
© Yang et al; licensee BioMed Central Ltd. 2011
【 预 览 】
Files | Size | Format | View |
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RO202311108404296ZK.pdf | 358KB | download |
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