Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women

Reproductive Biology and Endocrinology

Research

Liying Yan¹  Binbin Tu¹  Jie Qiao¹  Qiufang Zhang¹  Nana Liu¹  Xue Zhang¹  Li Fu¹  Yanmin Ma² 

[1] Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191, Beijing, P.R, China;Reproductive Medical Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 100026, Beijing, P.R, China;

关键词: Insulin Resistance;    Polycystic Ovary Syndrome;    Congenital Adrenal Hyperplasia;    PCOS Patient;    Hyperandrogenism;   

DOI  :  10.1186/1477-7827-9-46

 received in 2010-12-18, accepted in 2011-04-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTribbles 3 (TRB3) affects insulin signalling by inhibiting insulin-stimulated Akt phosphorylation and subsequent activation. A single nucleotide polymorphism located in the second extron of the human TRB3 gene is thought to be associated with insulin resistance. The latter is a core abnormality in PCOS independent of obesity. The present study was designed to clarify the relationships of TRB3 Q84R polymorphism with PCOS in a Chinese women group.MethodsA case-control study with two groups: PCOS group (n = 336) and control group of infertility women for tubal and/or male factor (n = 116) was performed. Genotyping of the TRB3 R84 variant was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsThe frequency of genotype QQ in PCOS women was significantly lower, while genotype QR and RR were significantly higher than that in control group (p < 0.05). However, the difference disappeared after adjustment for BMI. At glucose1h, glucose2h and insulin2h point, the difference between QQ individuals and R84 allele carriers in PCOS women reached statistical significance during OGTT (p < 0.05).ConclusionsTRB3 Q84R polymorphism is associated with obesity and especially glucose metabolism and not associated with polycystic ovary syndrome because of compositional characteristics of phenotype in Chinese PCOS women.

【 授权许可】

Unknown   
© Zhang et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.