Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystıc ovary syndrome

Lipids in Health and Disease

Research

Gulinnaz E Alper¹  Sevki Cetinkalp²  Ahmet G Ozgen²  Fusun Saygılı²  Candeger Yılmaz²  Zengi Ayhan²  Mehmet Erdoğan²  Muammer Karadeniz³  Asli Tetik⁴  Vildan Cetintas⁴  Zuhal Eroglu⁴  Murat Olukman⁵  Murat Yalcın⁶ 

[1] Department of Biochemistry, Ege University School of Medicine, Izmir, Turkey;Department of Endocrinology, Ege University School of Medicine, Izmir, Turkey;Department of Endocrinology, Sifa University, Health Application and Research Center, Izmir, Turkey;Department of Medical Biology, Ege University School of Medicine, Izmir, Turkey;Department of Pharmacology, Ege University Hospital, Ege University School of Medicine, Izmir, Turkey;Division of Internal Medicine, Sifa University, Health Application and Research Center, Izmir, Turkey;

关键词: Congenital Adrenal Hyperplasia;    Homocystein Level;    DHEAS;    PCOS Patient;    Hyperandrogenism;   

DOI  :  10.1186/1476-511X-10-193

 received in 2011-08-18, accepted in 2011-10-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundObesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients.In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study.ResultsIn PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.ConclusionsWe found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.

【 授权许可】

CC BY   
© Karadeniz et al; licensee BioMed Central Ltd. 2011