The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

Reproductive Biology and Endocrinology

Research

Ekaterini Koiou¹  Ilias Katsikis¹  Dimitrios Delkos¹  Elena Tsourdi¹  Emmanuil Kalaitzakis¹  Eleni A Kandaraki¹  Dimitrios Panidis¹  Konstantinos Tziomalos² 

[1] Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece;First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece;

关键词: Luteinizing Hormone;    Polycystic Ovary Syndrome;    Congenital Adrenal Hyperplasia;    Normal Weight Woman;    Ovarian Volume;   

DOI  :  10.1186/1477-7827-8-151

 received in 2010-11-03, accepted in 2010-12-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary syndrome (PCOS). However, there are limited data on serum lipocalin-2 levels in patients with PCOS. The aim of the present study was to assess serum lipocalin-2 levels in PCOS.MethodsWe studied 200 patients with PCOS and 50 healthy female volunteers.ResultsSerum lipocalin-2 levels were slightly higher in women with PCOS compared with controls (65.4 +/- 34.3 vs. 60.3 +/- 26.0 ng/ml, respectively) but this difference did not reach statistical significance. In contrast, lipocalin-2 levels were higher in overweight/obese women with PCOS than in normal weight women with the syndrome (76.2 +/- 37.3 vs. 54.5 +/- 27.2 ng/ml, respectively; p < 0.001). Serum lipocalin-2 levels were also higher in overweight/obese controls compared with normal weight controls (70.1 +/- 24.9 vs. 50.5 +/- 23.7 ng/ml, respectively; p = 0.004). In the total study population (patients with PCOS and controls), lipocalin-2 levels were independently correlated with the body mass index (p < 0.001). In women with PCOS, lipocalin-2 levels were independently correlated with the waist (p < 0.001).ConclusionsObesity is associated with elevated serum lipocalin-2 levels. In contrast, PCOS does not appear to affect lipocalin-2 levels.

【 授权许可】

Unknown   
© Panidis et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.