Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg

Journal of Cardiovascular Magnetic Resonance

Research

Thomas F Floyd¹  Emile R Mohler²  Erin K Englund³  Zachary B Rodgers³  Felix W Wehrli³  Michael C Langham³  Cheng Li³ 

[1] Department of Anesthesiology, Stony Brook University Medical Center, 11794, Stony Brook, NY, USA;Department of Medicine, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA;Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, 19104, Philadelphia, PA, USA;

关键词: Peripheral artery disease;    Atherosclerosis;    Microvascular function;    Perfusion;    Dynamic oximetry;    T2*;    BOLD;    Reactive hyperemia;    Skeletal muscle;   

DOI  :  10.1186/1532-429X-15-70

 received in 2013-04-20, accepted in 2013-07-30,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe function of the peripheral microvascular may be interrogated by measuring perfusion, tissue oxygen concentration, or venous oxygen saturation (SvO2) recovery dynamics following induced ischemia. The purpose of this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement of perfusion, SvO2, and skeletal muscle T2*.MethodsPerfusion, Intravascular Venous Oxygen saturation, and T2* (PIVOT) is comprised of interleaved pulsed arterial spin labeling (PASL) and multi-echo gradient-recalled echo (GRE) sequences. During the PASL post-labeling delay, images are acquired with a multi-echo GRE to quantify SvO2 and T2* at a downstream slice location. Thus time-courses of perfusion, SvO2, and T2* are quantified simultaneously within a single scan. The new sequence was compared to separately measured PASL or multi-echo GRE data during reactive hyperemia in five young healthy subjects. To explore the impairment present in peripheral artery disease patients, five patients were evaluated with PIVOT.ResultsComparison of PIVOT-derived data to the standard techniques shows that there was no significant bias in any of the time-course-derived metrics. Preliminary data show that PAD patients exhibited alterations in perfusion, SvO2, and T2* time-courses compared to young healthy subjects.ConclusionSimultaneous quantification of perfusion, SvO2, and T2* is possible with PIVOT. Kinetics of perfusion, SvO2, and T2* during reactive hyperemia may help to provide insight into the function of the peripheral microvasculature in patients with PAD.

【 授权许可】

Unknown   
© Englund et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.