Neutrophil to lymphocyte ratio as the main predictor of peripheral artery disease in regular hemodialysis patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Siregar, R.H.^1 ; Muzasti, R.A.^2

Department of Internal Medicine, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia^1

Nephrology-Hypertension Division, Department of Internal Medicine, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia^2

关键词: Ankle-brachial indices;    Cardio-vascular disease;    Chronic kidney disease;    Cross-sectional study;    Independent predictors;    Multi variate analysis;    Peripheral artery disease;    Type 2 diabetes mellitus;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012109/pdf
DOI  :  10.1088/1755-1315/125/1/012109

来源: IOP

【 摘 要 】

Cardiovascular disease is the most inducer of morbidity and mortality of chronic kidney disease (CKD) patients who have undergone dialysis. Today, neutrophil to lymphocyte ratio (NLR) is considered an indicator of the severity and extent of systemic inflammation and atherosclerosis in patients with renal and cardiovascular disorders. To examine the relationship between NLR with PAD in regular hemodialysis patients, a cross-sectional study, Ankle- Brachial Index (ABI) measurement and peripheral blood examination was on 72 regular hemodialysis patients ≥6 months. The ABI value ≤0.9 is considered PAD. NLR≥ 3.5 is considered abnormal based on some pre-existing research. Prevalence of PAD is 29.16%. Chi- square test showed significant correlation between NLR with PAD (p = 0.0001), multiplication of Calcium and Phosphorus (p = 0.0001), and type 2 Diabetes Mellitus (T2DM) (p = 0.039), multivariate analysis showed that NLR was an independent predictor for PAD in regular hemodialysis patients (RR = 2.271 p = 0.027). In conclusion, NLR, a new inflammatory marker of peripheral blood examination may serve as a marker of PAD in a regular hemodialysis patient, in addition to the multiplication of Calcium and Phosphorus as well as T2DM.