The weak correlation between serum vitamin levels and chronic kidney disease in hospitalized patients: a cross-sectional study

BMC Nephrology

Guangyan Cai¹  Pu Chen¹  Pengfei He¹  Ying Zheng¹  Shuang Liang¹  Xiaolei Shao¹  Yong Wang¹  Xiangmei Chen¹ 

[1] Department of Nephrology, State Key Laboratory of Kidney Diseases, First Medical Center of Chinese People’s Liberation Army General Hospital, Chinese People’s Liberation Army Institute of Nephrology, National Clinical Research Center for Kidney Diseases;

关键词: Chronic kidney disease;    Glomerular filtration rate;    Vitamin;    Deficiency;    Cross-sectional study;   

DOI  :  10.1186/s12882-021-02498-5

来源: DOAJ

【 摘 要 】

Abstract Background Chronic kidney disease (CKD) has become a global public health problem. Accumulating evidence suggested that vitamins play important roles in the progression of CKD. Methods A cross-sectional study was conducted to investigate the vitamin status of patients with CKD at stage 1–5. The serum concentrations of 9 vitamins, vitamin A, B1, B2, B6, B9, B12, C, D, and E were measured by electroanalytical method with a Multi-Vitamin Analyzer. Pearson correlation and multiple linear regression between serum level of vitamins were analyzed. Results The median levels of vitamin A, B1, B2, B6, B9, B12, C and E were within the reference ranges or on the borderline. Vitamin D deficiency was found in all patients. Weak correlation was found between vitamin A or vitamin D and estimated glomerular filtration rate (eGFR). The Pearson correlation coefficient were − 0.21766 and 0.19752, respectively. Hypertension, diabetes mellitus, and atherosclerosis were the major comorbidities. Conclusions For the first time, the serum levels of 9 vitamins were measured simultaneously in patients with CKD at different stages. Vitamin D deficiency was found in all patients. Weak correlation between vitamin A or vitamin D and eGFR was found.

【 授权许可】

Unknown