Estimating glomerular filtration rate in oncology patients receiving Cisplatin chemotherapy: Predicted creatinine clearance against 99mTc-DTPA methods

10th International Seminar on Medical Physics; 1st AMDI International Oncology Symposium

物理学;医药卫生

Syed Sahab, Sharifah Khaidah^1,2 ; Manap, Mahayuddin^1,2 ; Hamzah, Fadzilah^2

Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang

13200, Malaysia^1

Nuclear Medicine Department, Penang Hospital, Pulau Pinang, Georgetown

10450, Malaysia^2

关键词: Anticancer treatment;    Bland-altman plots;    Degree of reliability;    Glomerular filtration rate;    Intraclass correlation coefficients;    Prospective study;    Renal scintigraphy;    Therapeutic potentials;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012039/pdf
DOI  :  10.1088/1742-6596/851/1/012039

学科分类：卫生学

来源: IOP

【 摘 要 】

The therapeutic potential of cisplatin as the best anticancer treatment for solid tumor is limited by its potential nephrotoxicity. This study analyses the incidence of cisplatin induced nephrotoxicity in oncology patients through GFR estimation using99mTc-DTPA plasma sampling (reference method) and to compare with predicted creatinine clearance and Tc-99m renal scintigraphy. A prospective study of 33 oncology patients referred for GFR estimation in Penang Hospital. The incidence of cisplatin induced nephrotoxicity was analysed via radionuclide and creatinine based method. Of 33 samples, only 21 selected for the study. The dose of cisplatin given was 75 mg/m2for each cycle. The mean difference of GFR pre and post chemotherapy (PSC 2) was 13.38 (-4.60, 31.36) ml/min/1.73m2 (p 0.136). Of 21 patients, 3 developed severe nephrotoxicity (GFR 2) contributing 14.3% of incidence. Bland-Altman plot showed only PSC 1 is in agreement with PSC 2 technique. Intraclass Correlation Coefficients (ICC) also showed that PSC 1 has high degree of reliability in comparison to PSC 2 (p