Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg

Journal of Cardiovascular Magnetic Resonance

Felix W Wehrli²  Emile R Mohler¹  Thomas F Floyd³  Zachary B Rodgers²  Cheng Li²  Michael C Langham²  Erin K Englund² 

[1] Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA;Department of Anesthesiology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA

关键词: Skeletal muscle;    Reactive hyperemia;    BOLD;    T2*;    Dynamic oximetry;    Perfusion;    Microvascular function;    Atherosclerosis;    Peripheral artery disease;   

Others  :  812205
DOI  :  10.1186/1532-429X-15-70

 received in 2013-04-20, accepted in 2013-07-30,  发布年份 2013

【 摘 要 】

Background

The function of the peripheral microvascular may be interrogated by measuring perfusion, tissue oxygen concentration, or venous oxygen saturation (SvO₂) recovery dynamics following induced ischemia. The purpose of this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement of perfusion, SvO₂, and skeletal muscle T₂*.

Methods

Perfusion, Intravascular Venous Oxygen saturation, and T₂* (PIVOT) is comprised of interleaved pulsed arterial spin labeling (PASL) and multi-echo gradient-recalled echo (GRE) sequences. During the PASL post-labeling delay, images are acquired with a multi-echo GRE to quantify SvO₂ and T₂* at a downstream slice location. Thus time-courses of perfusion, SvO₂, and T₂* are quantified simultaneously within a single scan. The new sequence was compared to separately measured PASL or multi-echo GRE data during reactive hyperemia in five young healthy subjects. To explore the impairment present in peripheral artery disease patients, five patients were evaluated with PIVOT.

Results

Comparison of PIVOT-derived data to the standard techniques shows that there was no significant bias in any of the time-course-derived metrics. Preliminary data show that PAD patients exhibited alterations in perfusion, SvO₂, and T₂* time-courses compared to young healthy subjects.

Conclusion

Simultaneous quantification of perfusion, SvO₂, and T₂* is possible with PIVOT. Kinetics of perfusion, SvO₂, and T₂* during reactive hyperemia may help to provide insight into the function of the peripheral microvasculature in patients with PAD.

【 授权许可】

   
2013 Englund et al.; licensee BioMed Central Ltd.

【 图 表 】

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