Admission hyperglycemia and adverse outcomes in diabetic and non-diabetic patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention

BMC Cardiovascular Disorders

Research Article

Guodong Yang¹  Tao Li¹  Yuanyuan Hao¹  Peijing Hu¹  Qun Lu¹  Aiqun Ma² 

[1] Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China;Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China;Shaanxi Key Laboratory of Molecular Cardiology (Xi’an Jiaotong University), Xi’an, China;Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education, Xi’an, China;

关键词: Non-ST-elevation myocardial infarction;    Diabetes mellitus;    Hyperglycemia;    Major adverse cardiac events;   

DOI  :  10.1186/s12872-016-0441-x

 received in 2016-05-06, accepted in 2016-12-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe association between admission hyperglycemia and adverse outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI) has not been well studied, and the optimal plasma glucose cut-off values for prognosis for NSTEMI patients with and without diabetes have not been determined.MethodsAccording to glucose level and diabetes status, consecutive NSTEMI patients undergoing PCI (n = 890) were divided into four groups: without diabetes mellitus (DM) and admission plasma glucose (APG) <144 or ≥144 mg/dL; or with DM and APG <180 or ≥180 mg/dL. All patients were followed up at 30 days and 3 years after discharge, and the outcomes were assessed.ResultsAdmission hyperglycemia was found in 44 and 28% of the DM and non-DM patients, respectively. Multivariable analyses showed that the APG level was an independent predictor of 30-day and 3-year MACEs. Receiver operating characteristic curve analysis revealed that the appropriate cut-off values were 178 and 145 mg/dL for patients with and without DM, respectively, or 157 mg/dL for all patients.ConclusionsAdmission hyperglycemia may be used to predict 30-day and 3-year MACEs in patients with NSTEMI undergoing PCI, irrespective of diabetes status. However, the optimal admission glucose cut-off values for predicting prognosis differ for patients with or without DM.

【 授权许可】

CC BY   
© The Author(s). 2017