Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel

Journal of Biological Engineering

Research

Sergio Alberto Bernal-Chávez¹  Gerardo Leyva-Gómez²  Alejandra Romero-Montero²  Ma. De Los Dolores Campos-Echeverria²  Zainab M. Almarhoon³  Eda Sönmez Gürer⁴  Javad Sharifi-Rad⁵  Aknur Turgumbayeva⁶  Hernán Cortés⁷  Sergio Alcalá-Alcalá⁸  María Luisa Del Prado-Audelo⁹ 

[1] Departamento de Ciencias Químico-Biológicas, Universidad de Las Américas Puebla, Ex-Hda. de Sta. Catarina Mártir, 72820, Puebla, Cholula, Mexico;Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de Mexico, Mexico;Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, 11451, Riyadh, Saudi Arabia;Department of Pharmacognosy, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey;Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador;Higher School of Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan;School of Pharmacy, JSC “S.D. Asfendiyarov Kazakh National Medical University”, Almaty, Kazakhstan;Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Ciudad de México, Mexico;Laboratorio de Tecnología Farmacéutica, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico;Tecnologico de Monterrey, Campus Ciudad de México, 14380, Ciudad de Mexico, Mexico;

关键词: Cationic guar gum;    Hydrogel;    Poly(ethylene oxide);    Soft tissues;    Tissue engineering;    Wounds;   

DOI  :  10.1186/s13036-023-00376-2

 received in 2023-07-08, accepted in 2023-09-12,  发布年份 2023

来源: Springer

【 摘 要 】

Hydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent years, there has been a significant increase in the search for improved mechanical properties of hydrogels derived from natural products to extend their applications in various fields, and there are different methods to obtain strengthened hydrogels. Cationic guar gum has physicochemical properties that allow it to interact with other polymers and generate hydrogels. This study aimed to develop an ultra-stretchable and self-healing hydrogel, evaluating the influence of adding PolyOX [poly(ethylene oxide)] on the mechanical properties and the interaction with cationic guar gum for potential tissue engineering applications. We found that variations in PolyOX concentrations and pH changes influenced the mechanical properties of cationic guar gum hydrogels. After optimization experiments, we obtained a novel hydrogel, which was semi-crystalline, highly stretchable, and with an extensibility area of approximately 400 cm2, representing a 33-fold increase compared to the hydrogel before being extended. Moreover, the hydrogel presented a recovery of 96.8% after the self-healing process and a viscosity of 153,347 ± 4,662 cP. Therefore, this novel hydrogel exhibited optimal mechanical and chemical properties and could be suitable for a broad range of applications in different fields, such as tissue engineering, drug delivery, or food storage.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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