Crosstalk between autophagy and insulin resistance: evidence from different tissues

European Journal of Medical Research

Review

Alireza Bastin¹  Maryam Teimouri²  Maryam Niknam³  Reza Meshkani⁴  Maryam Shabani⁴  Mohammad Amin Momeni-Moghaddam⁵  Hamid Aria⁶  Hamed Akbari⁷  Asie Sadeghi⁷ 

[1] Clinical Research Development Center “The Persian Gulf Martyrs” Hospital, Bushehr University of Medical Sciences, Bushehr, Iran;Department of Biochemistry, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran;Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran;Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran;Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran;

关键词: Adipose tissue;    Autophagy;    Insulin resistance;    Diabetes complications;    Type 2 diabetes;   

DOI  :  10.1186/s40001-023-01424-9

 received in 2023-04-04, accepted in 2023-10-03,  发布年份 2023

来源: Springer

【 摘 要 】

Insulin is a critical hormone that promotes energy storage in various tissues, as well as anabolic functions. Insulin resistance significantly reduces these responses, resulting in pathological conditions, such as obesity and type 2 diabetes mellitus (T2DM). The management of insulin resistance requires better knowledge of its pathophysiological mechanisms to prevent secondary complications, such as cardiovascular diseases (CVDs). Recent evidence regarding the etiological mechanisms behind insulin resistance emphasizes the role of energy imbalance and neurohormonal dysregulation, both of which are closely regulated by autophagy. Autophagy is a conserved process that maintains homeostasis in cells. Accordingly, autophagy abnormalities have been linked to a variety of metabolic disorders, including insulin resistance, T2DM, obesity, and CVDs. Thus, there may be a link between autophagy and insulin resistance. Therefore, the interaction between autophagy and insulin function will be examined in this review, particularly in insulin-responsive tissues, such as adipose tissue, liver, and skeletal muscle.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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