The cGAS–STING pathway: more than fighting against viruses and cancer

Cell & Bioscience

Jia Liu¹  Jiyan Leng¹  Terigen Bao²  Lu Cai³ 

[1] Department of Geriatrics, The First Hospital of Jilin University, 130021, Changchun, China;Department of Geriatrics, The First Hospital of Jilin University, 130021, Changchun, China;Department of Pediatrics, The Pediatric Research Institute, The University of Louisville School of Medicine, 40292, Louisville, KY, USA;Department of Pediatrics, The Pediatric Research Institute, The University of Louisville School of Medicine, 40292, Louisville, KY, USA;Departments of Pharmacology and Toxicology, The University of Louisville School of Medicine, Louisville, KY, USA;

关键词: Anti-virus inflammation;    cGAS–STING pathway;    Diabetes;    Insulin resistance;    Diabetes complications;   

DOI  :  10.1186/s13578-021-00724-z

来源: Springer

【 摘 要 】

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control the production of type I interferon and nuclear factor kappa-light-chain-enhancer of activated B cells to promote the activation of pro-inflammatory molecules, which are mainly induced during antiviral responses. However, with progress in this area of research, studies focused on autoimmune diseases and chronic inflammatory conditions that may be relevant to cGAS–STING pathways have been conducted. This review mainly highlights the functions of the cGAS–STING pathway in chronic inflammatory diseases. Importantly, the cGAS–STING pathway has a major impact on lipid metabolism. Different research groups have confirmed that the cGAS–STING pathway plays an important role in the chronic inflammatory status in various organs. However, this pathway has not been studied in depth in diabetes and diabetes-related complications. Current research on the cGAS–STING pathway has shown that the targeted therapy of diseases that may be caused by inflammation via the cGAS–STING pathway has promising outcomes.

【 授权许可】

CC BY