期刊论文详细信息
Lipids in Health and Disease
Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro
Research
Shengrong Shen1  Feng Zhou1  Yuzhen Shen1  Hongzhou Meng2  Junhui Shen3  Undurti N Das4 
[1] Department of Food Science and Nutrition, School of Biosystems Engineering & Food Science, Zhejiang University, 310058, Hangzhou, China;Department of Urology, The First Affiliated Hospital, Zhejiang University, 310003, Hangzhou, China;School of Medicine, Tongji University, 200092, Shanghai, China;UND Life Sciences, 2020 S 360th St, K-202, 98003, Federal Way, WA, USA;School of Biotechnology, Jawaharlal Nehru Technological University, 533 003, Kakinada, India;Department of Medicine, GVP Hospital and Bio-Science Research Centre, Campus of GVP College of Engineering, 530 048, Visakhapatnam, India;
关键词: n-6 Polyunsaturated fatty acids;    n-3 Polyunsaturated fatty acids;    Prostate cancer;    Cytokines;    Free radicals;    Lipid peroxidation;    Lipoxin A4;   
DOI  :  10.1186/1476-511X-12-160
 received in 2013-07-17, accepted in 2013-10-25,  发布年份 2013
来源: Springer
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【 摘 要 】

Prostate cancer (PCa) is one of the leading causes of death in the elderly men. Polyunsaturated fatty acids (PUFAs) regulate proliferation of cancer cells. In the present study, we evaluated the effect of various PUFAs on the proliferation and survival of human prostate cancer (PC-3) and human prostate epithelial (RWPE-1) cells in vitro.LA, GLA, AA, ALA, EPA and DHA (linoleic acid, gamma-linolenic acid, arachidonic acid, alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid respectively) when tested at 50, 100, 150, and 200 μM inhibited proliferation of RWPE-1 and PC-3 cells, except that lower concentrations of LA (25 μM) and GLA (5, 10 μM) promoted proliferation. Though all fatty acids tested produced changes in the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), lipoxin A4 and free radical generation by RWPE-1 and PC-3 cells, there were significant differences in their ability to do so. As expected, supplementation of various n-3 and n-6 fatty acids to RWPE-1 and PC-3 cells enhanced the content of the added fatty acids and their long-chain metabolites in these cells. In contrast to previous results, we did not find any direct correlation between inhibition of cell proliferation induced by various fatty acids and free radical generation. These results suggest that polyunsaturated fatty acids suppress proliferation of normal and tumor cells by a variety of mechanisms that may partly depend on the type(s) of cell(s) being tested and the way these fatty acids are handled by the cells. Hence, it is suggested that more deeper and comprehensive studies are needed to understand the actions of fatty acids on the growth of normal and tumor cells.

【 授权许可】

Unknown   
© Meng et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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