High-resolution and accelerated multi-parametric mapping with automated characterization of vessel disease using intravascular MRI

Journal of Cardiovascular Magnetic Resonance

Research

Guan Wang¹  Paul A. Bottomley¹  Shashank Sathyanarayana Hegde²  Yi Zhang² 

[1] Department of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, USA;Division of MR Research, Department of Radiology and Radiological Sciences, Johns Hopkins University, Park building 310, 600 N Wolfe Street, 21287, Baltimore, MD, USA;Division of MR Research, Department of Radiology and Radiological Sciences, Johns Hopkins University, Park building 310, 600 N Wolfe Street, 21287, Baltimore, MD, USA;

关键词: Intravascular MRI;    Atherosclerosis;    Relaxation times;    Disease classification;    Accelerated acquisition;    SLAM;    Machine learning;   

DOI  :  10.1186/s12968-017-0399-6

 received in 2017-06-16, accepted in 2017-10-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAtherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular magnetic resonance imaging (IVMRI) measures of relaxation times (T1, T2) and proton density (PD) in a clinical 3 Tesla scanner could characterize vessel disease, and evaluates a practical strategy for accelerated quantification.MethodsIVMRI was performed in fresh human artery segments and swine vessels in vivo, using fast multi-parametric sequences, 1–2 mm diameter loopless antennae and 200–300 μm resolution. T1, T2 and PD data were used to train a machine learning classifier (support vector machine, SVM) to automatically classify normal vessel, and early or advanced disease, using histology for validation. Disease identification using the SVM was tested with receiver operating characteristic curves. To expedite acquisition of T1, T2 and PD data for vessel characterization, the linear algebraic method (‘SLAM’) was modified to accommodate the antenna’s highly-nonuniform sensitivity, and used to provide average T1, T2 and PD measurements from compartments of normal and pathological tissue segmented from high-resolution images at acceleration factors of R ≤ 18-fold. The results were validated using compartment-average measures derived from the high-resolution scans.ResultsThe SVM accurately classified ~80% of samples into the three disease classes. The ‘area-under-the-curve’ was 0.96 for detecting disease in 248 samples, with T1 providing the best discrimination. SLAM T1, T2 and PD measures for R ≤ 10 were indistinguishable from the true means of segmented tissue compartments.ConclusionHigh-resolution IVMRI measures of T1, T2 and PD with a trained SVM can automatically classify normal, early and advanced atherosclerosis with high sensitivity and specificity. Replacing relaxometric MRI with SLAM yields good estimates of T1, T2 and PD an order-of-magnitude faster to facilitate IVMRI-based characterization of vessel disease.

【 授权许可】

CC BY   
© The Author(s). 2017