Association of basal serum testosterone levels with ovarian response and in vitro fertilization outcome

Reproductive Biology and Endocrinology

Research

Li Che¹  Zhiyi Zhao²  Zi-Jiang Chen²  Yingying Qin²  Mei Sun²  Ling Geng² 

[1] Case Western Reserve University, 44146, Cleveland, OH, USA;Center for Reproductive Medicine, Shandong Provincial Hospital Shandong University, 250021, Jinan, PR, China;Key Laboratory of Reproductive Medicine, Shandong Province, PR, China;

关键词: Endometriosis;    Ovarian Reserve;    Ovarian Response;    Control Ovarian Hyperstimulation;    Antral Follicle Count;   

DOI  :  10.1186/1477-7827-9-9

 received in 2010-10-29, accepted in 2011-01-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo evaluate basal testosterone (T) levels during follicular phase of the menstrual cycle as a predictor for ovarian response and in vitro fertilization (IVF) outcome.MethodWe analyzed data retrospectively from hospital-based IVF center including one thousand two hundred and sixty Chinese Han women under their first IVF cycle reached the ovum pick-up stage, without polycystic ovary syndrome (PCOS) or endometriosis undergoing long IVF protocol. Patients were divided into 2 groups. Group 1: patients with diminished ovarian reserve (basal FSH >10 IU/L) (n = 187); Group 2: patients with normal ovarian reserve (basal FSH < = 10 IU/L) (n = 1073). We studied the association of basal T levels with ovarian response and IVF outcome in the two groups. Long luteal down-regulation protocol was used in all patients, that is, the gonadotropin releasing hormone agonist was administered in the midluteal phase of the previous cycle and use of recombinant FSH was started when satisfactory pituitary desensitization was achieved.ResultsBasal T levels were markly different between pregnant and non-pregnant women in Group 1; whereas not in Group 2. A testosterone level of 47.85 ng/dl was shown to predict pregnancy outcome with a sensitivity of 52.8% and specificity of 65.3%; and the basal T was correlated with the numbers of large follicles (> 14 mm) on HCG day in Group 1. Significantly negative correlations were observed between basal T, days of stimulation and total dose of gonadotropins after adjusting for confounding factors in both groups.ConclusionIn women with diminished ovarian reserve, basal T level was a predictor for the number of large follicles on HCG day and pregnancy outcome; but could not in those with normal serum FSH. Basal T levels were associated with both days of stimulation and total dose of gonadotropins, indicating that lower level of T might relate with potential ovarian poor response.

【 授权许可】

Unknown   
© Qin et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.