Effects of prolonging administration gonadotropin on unexpectedly poor ovarian responders undergoing in vitro fertilization

Reproductive Biology and Endocrinology

Methodology

Jun Li¹  Xianxia Cheng²  Yunxia Cao²  Lin Cong²  Ping Zhou²  Zhaolian Wei²  Huirong Li² 

[1] Pharmacological college, Anhui Medical University, 230022, Hefei, PR, China;Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, 230022, Hefei, PR, China;

关键词: Live Birth Rate;    Ovarian Reserve;    Poor Responder;    Ovarian Response;    Clinical Pregnancy Rate;   

DOI  :  10.1186/1477-7827-8-26

 received in 2009-12-14, accepted in 2010-03-17,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere are still some patients who show poor response to ovarian stimulation prior to evidence of normal ovarian reserve in vitro fertilization. However, there are few studies about how to treat the unexpectedly ovarian poor responder in vitro fertilization. The main aim of this study evaluate the effect of prolonging administration follicle-stimulating hormone in woman with the unexpectedly ovarian poor responder in vitro fertilization on implantation rate, clinical pregnancy rate and live birth rate.Methods922 patients subjected to IVF were divided into two groups according to the predicted criterion of ovarian poor response. 116 patients predicted poor response received the short protocol (group C). The others received the long protocol, among the latter, there were 149 patients undergoing unexpectedly ovarian poor response (group B) and 657 patients exhibited normal ovarian response (group A). The doses of gonadotropin, duration of administration, implantation rate, clinical pregnancy rate and live birth rate were recorded among three groups.ResultsThe implantation rate of embryo, clinic pregnancy rate and delivery rate are similar between the group A and group B, while there are significant differences between the doses of gonadotropins (35.1 +/- 8.9 ampules vs.53.0 +/- 15.9 ampules) and the duration of administration (15.3 +/- 3.6D vs. 9.8 +/- 2.6D) of these two groups. There are no significant differences about clinical pregnancy rate and live birth rate between group B and group C.ConclusionProlonging administration gonadotropin on the unexpectedly poor ovarian responders does not lower live birth rate in vitro fertilization.

【 授权许可】

Unknown   
© Wei et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.