Ovarian sensitivity index is strongly related to circulating AMH and may be used to predict ovarian response to exogenous gonadotropins in IVF

Reproductive Biology and Endocrinology

Research

Angela Bertagna¹  Chiara Manieri¹  Paola Dalmasso²  Valentina Biasoni³  Ambra Patriarca³  Chiara Benedetto³  Alberto Revelli³ 

[1] Endocrinology Laboratory, Department. of Internal Medicine, A.O.U.S. Giovanni Battista, University of Torino, Italy;Medical Statistics Unit, Department of Public Health and Microbiology, University of Torino, Torino, Italy;Physiopathology of Reproduction and IVF Unit, University of Torino, S.Anna Hospital, Torino, Italy;

关键词: Follicular Fluid;    Ovarian Stimulation;    Ovarian Reserve;    Ovarian Response;    Buserelin;   

DOI  :  10.1186/1477-7827-9-112

 received in 2011-06-11, accepted in 2011-08-09,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundSerum anti-Mullerian hormone (AMH) is currently considered the best marker of ovarian reserve and of ovarian responsiveness to gonadotropins in in-vitro fertilization (IVF). AMH assay, however, is not available in all IVF Units and is quite expensive, a reason that limits its use in developing countries. The aim of this study is to assess whether the "ovarian sensitivity index" precisely reflects AMH so that this index may be used as a surrogate for AMH in prediction of ovarian response during an IVF cycle.MethodsAMH serum levels were measured in 61 patients undergoing IVF with a "long" stimulation protocol including the GnRH agonist buserelin and recombinant follicle-stimulating hormone (rFSH). Patients were divided into four subgroups according to the percentile of serum AMH and their ovarian stimulation was prospectively followed. Ovarian sensitivity index (OSI) was calculated dividing the total administered FSH dose by the number of retrieved oocytes.ResultsAMH and OSI show a highly significant negative correlation (r = -0.67; p = 0.0001) that is stronger than the one between AMH and the total number of retrieved oocytes and than the one between AMH and the total FSH dose.ConclusionsOSI reflects quite satisfactory the AMH level and may be proposed as a surrogate of AMH assay in predicting ovarian responsiveness to FSH in IVF. Being very easy to calculate and costless, its use could be proposed where AMH measurement is not available or in developing countries where limiting costs is of primary importance.

【 授权许可】

Unknown   
© Biasoni et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.