The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels

Reproductive Biology and Endocrinology

Research

Fang-Ju Sun¹  Sheng-Hsiang Li¹  Frank Shao-Ying Wu²  Ming-Huei Lin²  Robert Kuo-Kuang Lee³  Yuh-Ming Hwu⁴ 

[1] Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan;Mackay Medicine, Nursing and Management College, Taipei, Taiwan;Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;

关键词: Endometriosis;    Cystectomy Group;    Congenital Adrenal Hyperplasia;    Inhibin;    Ovarian Reserve;   

DOI  :  10.1186/1477-7827-9-80

 received in 2011-03-08, accepted in 2011-06-09,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundSerum anti-Müllerian hormone (AMH) had been proposed as a marker of ovarian reserve. The aim of this study was to evaluate the impact of endometrioma and laparoscopic cystectomy on ovarian reserve as measured by serum AMH levels.MethodsA total of 1,642 patients were recruited in this retrospective analysis. Control group (group 1) included 1,323 infertility patients without endometrioma. Endometrioma group (group 2) included 141 patients with ovarian endometrioma. Previous cystectomy group (group 3) included 147 patients who underwent unilateral or bilateral laparoscopic cystectomy due to ovarian endometrioma more than 6 months before enrollment. Current cystectomy group (group 4) included 31 patients who underwent cystectomy during study period. Serum anti-müllerian hormone (AMH) levels were measured upon enrollment with all patients. For patients in group 4, AMH levels were measured before and 3 months after cystectomy.ResultsMean AMH level of patients in control group was significantly higher than that of endometrioma group or previous cystectomy group in each age subgroup, while the mean serum AMH level of the endometrioma group was also significantly higher than that of the previous cystectomy group in each age subgroup. The mean AMH level was significantly lower in patients with previous bilateral cystectomy compared to that of patients with unilateral cystectomy. The mean serum AMH level was also significantly lower in patients with bilateral endometrioma compared to that of patients with unilateral endometrioma. In group 4, mean AMH level significantly decreased from 3.95 +/- 0.42 preoperation to 2.01 +/- 0.21 ng/ml at 3-month postoperation.ConclusionsBoth ovarian endometrioma and cystectomy are associated with a significant reduction on ovarian reserve. Bilateral endometrioma exerts a more profound negative impact on ovarian reserve than unilateral endometrioma, regardless of either conservative or surgical intervention.

【 授权许可】

Unknown   
© Hwu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.