Understanding the impact of symptoms on the burden of COPD

Respiratory Research

Review

Anna Ribera¹  Marc Miravitlles² 

[1] AstraZeneca PLC, Avda. Diagonal 615, 08028, Barcelona, Spain;Pneumology Department, Vall d’Hebron University Hospital, CIBER de Enfermedades Respiratorias (CIBERES), P. de la Vall d’Hebron 119-129, 08035, Barcelona, Spain;

关键词: Chronic obstructive pulmonary disease;    Symptoms;    Burden;    Variability;    Patient-reported outcomes;   

DOI  :  10.1186/s12931-017-0548-3

 received in 2017-02-25, accepted in 2017-04-07,  发布年份 2017

来源: Springer

【 摘 要 】

Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightness) of varying severities. We present an overview of the biomedical literature describing reported relationships between COPD symptoms and disease burden in terms of quality of life, health status, daily activities, physical activity, sleep, comorbid anxiety, and depression, as well as risk of exacerbations and disease prognosis. In addition, the substantial variability of COPD symptoms encountered (morning, daytime, and nighttime) is addressed and their implications for disease burden considered. The findings from this narrative review, which mainly focuses on real-world and observational studies, demonstrate the impact of COPD symptoms on the burden of disease and that improved recognition and understanding of their impact is central to alleviating this burden.

【 授权许可】

CC BY   
© The Author(s). 2017