Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension

Cardiovascular Diabetology

Original Investigation

Ursula Matte¹  Fernanda Sperb¹  Aline Marcadenti²  Flavio D Fuchs³  Sandra C Fuchs³  Leila B Moreira³ 

[1] Center for Gene Therapy, Hospital de Clínicas de Porto Alegre, R. Ramiro Barcelos 2600, 1º. andar, Porto Alegre, RS, Brazil;Postgraduate Studies Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos 2600, 2º. andar, Porto Alegre, RS, Brazil;Postgraduate Studies Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos 2600, 2º. andar, Porto Alegre, RS, Brazil;Division of Cardiology, Hospital de Clínicas de Porto Alegre, and the National Institute for Science and Technology for Health Technology Assessment (IATS/CNPq), R. Ramiro Barcelos 2600, 2º. andar, Porto Alegre, RS, Brazil;

关键词: Diabetes mellitus;    Hypertension;    FTO;    MC4R;    Waist circumference;    Neck circumference;    Lipid Accumulation Product index;    Body mass index;   

DOI  :  10.1186/1475-2840-12-103

 received in 2013-02-13, accepted in 2013-07-10,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundGenetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity. Individuals with mutations in MC4R gene have lower blood pressure (BP), independently of obesity. This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.MethodsWe genotyped 217 individuals (86 men and 131 women) with hypertension (systolic or diastolic BP ≥ 140/90 mmHg or using antihypertensive drugs). Diabetes mellitus was diagnosed according to the American Diabetes Association criteria. Waist and neck circumferences (cm), Body Adiposity Index (BAI,%), Lipid Accumulation Product Index (LAP, cm.mmol.l) and body mass index (BMI, kg/m2) were analyzed using analysis of covariance or modified Poisson’s regression.ResultsRare allele frequencies were 0.40 for A for FTO rs9939609 and 0.18 for C for MC4R rs17782313. A positive association of FTO rs9939609 and MC4R rs17782313 with BMI was observed in the overall sample. Among men and women, neck circumference was associated with the FTO genotype and, for women, MC4R genotype. In contrast, in men we found a negative association of MC4R rs17782313 with diastolic BP (TT 90.1 ±12.2, TC/CC 83.2 ±12.1; P = 0.03) and borderline association for systolic BP after controlling for age and BMI.ConclusionsCommon genetic variants of FTO rs9939609 have positive associations with BMI and neck circumference and MC4R rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension.

【 授权许可】

Unknown   
© Marcadenti et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.