Intra-thoracic fat volume is associated with myocardial infarction in patients with metabolic syndrome

Journal of Cardiovascular Magnetic Resonance

Research

Umjeet S Jolly¹  Tisha Joy²  James A White³  John Stirrat⁴  Matthew Brymer⁴  Immaculate Nevis⁴  Abraam Soliman⁵  Maria Drangova⁶  Charles McKenzie⁷  Terry Peters⁷ 

[1] Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada;Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada;Cardiovascular MRI Clinical Research (CMCR) Program, London Health Sciences Center, 339 Windermere Road, N6A 5A5, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Biomedical Engineering, University of Western Ontario, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada;Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada;Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada;

关键词: Fat distribution;    Adiposity;    Metabolic syndrome;    Myocardial infarction;   

DOI  :  10.1186/1532-429X-15-77

 received in 2013-02-28, accepted in 2013-08-22,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundVisceral adiposity is increased in those with Metabolic Syndrome (MetS) and atherosclerotic disease burden. In this study we evaluate for associations between intra-thoracic fat volume (ITFV) and myocardial infarction (MI) in patients with MetS.MethodsNinety-four patients with MetS, MI or both were identified from a cardiovascular CMR clinical registry. MetS was defined in accordance to published guidelines; where-as MI was defined as the presence of subendocardial-based injury on late gadolinium enhancement imaging in a coronary vascular distribution. A healthy control group was also obtained from the same registry. Patients were selected into the following groups: MetS+/MI- (N = 32), MetS-/MI + (N = 30), MetS+/MI + (N = 32), MetS-/MI- (N = 16). ITFV quantification was performed using signal threshold analysis of sequential sagittal CMR datasets (HASTE) and indexed to body mass index.ResultsThe mean age of the population was 59.8 ± 12.5 years. MetS+ patients (N=64) demonstrated a significantly higher indexed ITFV compared to MetS- patients (p = 0.05). Patients in respective MetS-/MI-, MetS+/MI-, MetS-/MI+, and MetS+/MI + study groups demonstrated a progressive elevation in the indexed ITFV (22.3 ± 10.6, 28.6 ± 12.6, 30.6 ± 12.3, and 35.2 ± 11.4 ml/kg/m2, (p = 0.002)). Among MetS+ patients those with MI showed a significantly higher indexed ITFV compared to those without MI (p = 0.02).ConclusionsITFV is elevated in patients with MetS and incrementally elevated among those with evidence of prior ischemic myocardial injury. Accordingly, the quantification of ITFV may be a valuable marker of myocardial infarction risk among patients with MetS and warrants further investigation.

【 授权许可】

Unknown   
© Jolly et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.