Intra-thoracic fat volume is associated with myocardial infarction in patients with metabolic syndrome

Journal of Cardiovascular Magnetic Resonance

James A White⁴  Maria Drangova²  Tisha Joy¹  Matthew Brymer¹  Immaculate Nevis¹  John Stirrat¹  Terry Peters²  Charles McKenzie²  Abraam Soliman⁵  Umjeet S Jolly³ 

[1] Robarts Research Institute, University of Western Ontario, London, Ontario, Canada;Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada;Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada;Cardiovascular MRI Clinical Research (CMCR) Program, London Health Sciences Center, 339 Windermere Road, London, Ontario N6A 5A5, Canada;Biomedical Engineering, University of Western Ontario, London, Ontario, Canada

关键词: Myocardial infarction;    Metabolic syndrome;    Adiposity;    Fat distribution;   

Others  :  805451
DOI  :  10.1186/1532-429X-15-77

 received in 2013-02-28, accepted in 2013-08-22,  发布年份 2013

【 摘 要 】

Background

Visceral adiposity is increased in those with Metabolic Syndrome (MetS) and atherosclerotic disease burden. In this study we evaluate for associations between intra-thoracic fat volume (ITFV) and myocardial infarction (MI) in patients with MetS.

Methods

Ninety-four patients with MetS, MI or both were identified from a cardiovascular CMR clinical registry. MetS was defined in accordance to published guidelines; where-as MI was defined as the presence of subendocardial-based injury on late gadolinium enhancement imaging in a coronary vascular distribution. A healthy control group was also obtained from the same registry. Patients were selected into the following groups: MetS+/MI- (N = 32), MetS-/MI + (N = 30), MetS+/MI + (N = 32), MetS-/MI- (N = 16). ITFV quantification was performed using signal threshold analysis of sequential sagittal CMR datasets (HASTE) and indexed to body mass index.

Results

The mean age of the population was 59.8 ± 12.5 years. MetS+ patients (N=64) demonstrated a significantly higher indexed ITFV compared to MetS- patients (p = 0.05). Patients in respective MetS-/MI-, MetS+/MI-, MetS-/MI+, and MetS+/MI + study groups demonstrated a progressive elevation in the indexed ITFV (22.3 ± 10.6, 28.6 ± 12.6, 30.6 ± 12.3, and 35.2 ± 11.4 ml/kg/m2, (p = 0.002)). Among MetS+ patients those with MI showed a significantly higher indexed ITFV compared to those without MI (p = 0.02).

Conclusions

ITFV is elevated in patients with MetS and incrementally elevated among those with evidence of prior ischemic myocardial injury. Accordingly, the quantification of ITFV may be a valuable marker of myocardial infarction risk among patients with MetS and warrants further investigation.

【 授权许可】

   
2013 Jolly et al.; licensee BioMed Central Ltd.

【 图 表 】

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