Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis

Journal of Translational Medicine

Research

Stefano Mori¹  Nicola Mozzillo¹  Massimiliano Di Marzo¹  Gianluca Di Monta¹  Corrado Caracò¹  Ugo Marone¹  Lucia Festino²  Antonio Maria Grimaldi²  Paolo Antonio Ascierto²  Vito Vanella²  Marco Palla²  Ester Simeone² 

[1] Department of Surgery “Melanoma-Soft Tissues-Head & Neck-Skin Cancers”, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy;Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy;

关键词: Electrochemotherapy;    Electroporation;    Squamous cell carcinoma;   

DOI  :  10.1186/s12967-017-1186-8

 received in 2016-12-16, accepted in 2017-04-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundExtensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new potential option and may be considered as an alternative treatment. The aim of this retrospective single-center study was to evaluate electrochemotherapy efficacy in treatment of locally advanced stage III squamous cell carcinoma, in which surgical procedures would have entailed wide tissue sacrifice.MethodsClinical features, treatment response, and adverse effects were evaluated in 22 patients treated with electrochemotherapy with intravenous injection of bleomycin for extensive stage III cutaneous squamous cell carcinoma. Treatment of cutaneous lesions were performed according to the European Standard Operating Procedures of Electrochemotherapy.ResultsOverall response to electrochemotherapy treatment was observed in 18 (81.8%) patients. Clinical response with necrosis of tumor mass was observed from the first session and lasted for all follow up period that ranged between 5 and 48 months with a median of 34 months. Overall the treatment was well tolerated with a very low complication rate.ConclusionsElectrochemotherapy represents a safe and effective therapeutic approach, associated with a good tolerability.

【 授权许可】

CC BY   
© The Author(s) 2017