Modelling in conventional electroporation for model cell with organelles using COMSOL Multiphysics

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Sulaeman, M.Y.^1 ; Widita, R.^1

Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesa 10, Bandung

40132, Indonesia^1

关键词: Cancer tissues;    Comsol multiphysics;    Electrochemotherapy;    Electroporation;    External electric field;    Pore densities;    Potential distributions;    Transmembrane voltage;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012072/pdf
DOI  :  10.1088/1742-6596/694/1/012072

学科分类：卫生学

来源: IOP

【 摘 要 】

Conventional electroporation is a formation of pores in the membrane cell due to the external electric field applied to the cell. The purpose of creating pores in the cell using conventional electroporation are to increase the effectiveness of chemotherapy (electrochemotherapy) and to kill cancer tissue using irreversible electroporation. Modeling of electroporation phenomenon on a model cell had been done by using software COMSOL Multiphysics 4.3b with the applied external electric field with intensity at 1.1 kV/cm to find transmembrane voltage and pore density. It can be concluded from the results of potential distribution and transmembrane voltage, it show that pores formation only occurs in the membrane cells and it could not penetrate into inside the model cell so there is not pores formation in its organells.