Hydrodynamic Assists Magnetophoreses Rare Cancer cells Separation in Microchannel Simulation and Experimental Verifications

International Conference on Nanomaterials and Biomaterials 2017

材料科学;物理学;生物科学

Saeed, O.^1,2 ; Duru, L.^1 ; Yulin, D.^1

School of Life Science, Department of Biomedical Engineering, Beijing Institute of Technology, Beijing

100081, China^1

Faculty of Science and Technology, Department of Biomedical Physics, AL-Neelain University, Khartoum

1121, Sudan^2

关键词: Cell mixtures;    Comsol multiphysics;    Magnetic mechanisms;    Magnetic techniques;    Optimal conditions;    Physical model;    Separation process;    Simulation and experimental verifications;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/350/1/012013/pdf
DOI  :  10.1088/1757-899X/350/1/012013

来源: IOP

【 摘 要 】

A proposed microfluidic design has been fabricated and simulated using COMSOL Multiphysics software, based on two physical models included in this design. The device's ability to create a narrow stream of the core sample by controlling the sheath flow rates Qs1 and Qs2 in both peripheral channels was investigated. The main target of this paper is to study the possibility of combing the hydrodynamic and magnetic techniques, in order to achieve a high rate of cancer cells separation from a cell mixture and/or buffer sample. The study has been conducted in two stages, firstly, the effects of the sheath flow rates (Qs1 and Qs2) on the sample stream focusing were studied, to find the proposed device effectiveness optimal conditions and its capability in cell focusing, and then the magnetic mechanism has been utilized to finalize the pre-labelled cells separation process.