Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser

Lipids in Health and Disease

Research

Reem El Gebaly¹  Maha Fadel²  Magdy M. Ghannam³ 

[1] Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt;Department of Applied Laser Tech, National Institute of Laser Sc, Cairo University, Giza, Egypt;Department of Physics and Astronomy, King Saud University, Riyadh, Saudi Arabia;Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt;

关键词: Liposomes;    Doxorubicin;    Diode laser;    Anticancer;   

DOI  :  10.1186/s12944-016-0235-2

 received in 2016-01-23, accepted in 2016-03-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe use of liposomes as drug delivery systems is the most promising technique for targeting drug especially for anticancer therapy.MethodsIn this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover, the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid tumor were also studied.ResultsThe results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 °C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is a promising method in cancer therapy.ConclusionWe can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5°C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in mice and eliminated toxic side effects of doxorubicin.

【 授权许可】

CC BY   
© Ghannam et al. 2016