Photoresponsive Liposomes for Anticancer Photothermal Therapy

Liposomes;Near infrared light;Bio-inspired surface modification;Biocompatibility;Photothermal therapy;Chemotherapy;615

약학대학 약학과 ;

University:서울대학교 대학원

关键词: Liposomes;    Near infrared light;    Bio-inspired surface modification;    Biocompatibility;    Photothermal therapy;    Chemotherapy;    615;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133634/1/000000133654.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

this type of adhesive coating method was selectively derived from the adhesive mechanism of the mussels and is widely used for its biocompatibility. The experimental results showed various promising effects. First the temperature of modified photo-responsive liposomes increased about 69 oC (at maximum) above that of the control group under the NIR light, which in turn brought photo-thermal effect of the cancer cells. The results of in vitro efficacy tests of the modified liposomes showed low cell viability compared to other two groups - untreated and normal liposomes. Lastly, the liposomal delivery of Edelfosine - one of the most common anti-cancer drugs - reduced viability of the cancer cells remarkably after PTT. Overall, this development of the photo-responsive liposomes, encapsulating anticancer drug, suggests combinatorial chemo- and photothermal- therapy as a new approach to the development of future anticancer medicines.