Genomic, transcriptomic and epigenomic sequencing data of the B-cell leukemia cell line REH

BMC Research Notes

Data Note

Lars Feuk¹  Susanne Hellstedt Kerje¹  Adam Ameur¹  Mai-Britt Mosbech¹  Anna Petri¹  Ignas Bunikis¹  Susana Häggqvist¹  Yanara Marincevic-Zuniga²  Jon Ramsell²  Ann-Christin Wiman²  Mariya Lysenkova Wiklander²  Elin Övernäs²  Sara Ekberg²  Ulrika Liljedahl²  Amanda Raine²  Pontus Larsson²  Rikard Erlandsson²  Tom Martin²  Jessica Nordlund²  Henrik Gezelius²  Johanna Lagensjö² 

[1] Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden;Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Box 1432, SE-751 44, Uppsala, Sweden;

关键词: Next-generation sequencing;    Long-read;    Short-read;    Multi-omics;    Genomics;    Transcriptomics;    Epigenomics;    B-ALL;    Cell line;    Digital karyotype;   

DOI  :  10.1186/s13104-023-06537-2

 received in 2023-04-20, accepted in 2023-09-25,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesThe aim of this data paper is to describe a collection of 33 genomic, transcriptomic and epigenomic sequencing datasets of the B-cell acute lymphoblastic leukemia (ALL) cell line REH. REH is one of the most frequently used cell lines for functional studies of pediatric ALL, and these data provide a multi-faceted characterization of its molecular features. The datasets described herein, generated with short- and long-read sequencing technologies, can both provide insights into the complex aberrant karyotype of REH, and be used as reference datasets for sequencing data quality assessment or for methods development.Data descriptionThis paper describes 33 datasets corresponding to 867 gigabases of raw sequencing data generated from the REH cell line. These datasets include five different approaches for whole genome sequencing (WGS) on four sequencing platforms, two RNA sequencing (RNA-seq) techniques on two different sequencing platforms, DNA methylation sequencing, and single-cell ATAC-sequencing.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023