Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer

Molecular Cancer

Letter to the Editor

Jingfan Chen¹  Hongzhen Zhu²  Xuexiang Liu²  Meiyu Dai²  Xiaoli Chen²  Zhizhuo Huang²  Yujie Huang²  Jinwan Li²  Shengming Dai³ 

[1] Department of General Surgery, the Fourth Affiliated Hospital of Guangxi Medical University, 545005, Liuzhou, Guangxi, China;No.1 LIUSHI Rd, 545005, Liuzhou city, Guangxi Province, China;Medical Science Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, 545005, Liuzhou, Guangxi, China;Medical Science Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, 545005, Liuzhou, Guangxi, China;No.1 LIUSHI Rd, 545005, Liuzhou city, Guangxi Province, China;

关键词: Long non-coding RNA;    BLACAT1;    Cancer;    TCGA;    Diagnosis;    Prognosis;   

DOI  :  10.1186/s12943-017-0728-2

 received in 2017-07-14, accepted in 2017-09-28,  发布年份 2017

来源: Springer

【 摘 要 】

A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers in cancers. However, these studies often revealed the changes of lncRNAs within a specific cancer type. Here, we focused on BLACAT1 and provided a comprehensive pan-cancer analysis to evaluate the diagnostic and prognostic values of BLACAT1. The expression data of BLACAT1 were came from the quantitative real-time polymerase chain reaction (qRT-PCR) and The Cancer Genome Atlas (TCGA) database, respectively. Our results showed that the change of serum BLACAT1 expression was similar to those in matched tissues. The expression level of BLACAT1 both in serum and tissues in multiple cancer types were significantly upregulated compared to those of matched non-cancer participants. The serum BLACAT1 had a high diagnostic performance among these 12 types of cancer. The relative AUC of serum BLACAT1 in cancer patients ranged from 0.833 to 0.967 compared to that in healthy subjects. Surprisingly, Kaplan-Meier survival analysis revealed that the high expression level of BLACAT1 was significantly associated with poor overall survival only in uterine corpus endometrial carcinoma (p = 0.002, log-rank test). These findings demonstrated that BLACAT1 could act as a non-specific diagnostic biomarker for cancers and a potential biomarker for prognosis prediction of endometrial cancer.

【 授权许可】

CC BY   
© The Author(s). 2017