Long non-coding RNA XIST: a novel oncogene in multiple cancers

Molecular Medicine

Manlong Qi¹  Jun Yang²  Kefeng Wang³  Xia Wang³  Xiang Fei³ 

[1] Department of Clinical Genetics, Shengjing Hospital of China Medical University, 110004, Shenyang, China;Department of Gastroenterology, Shengjing Hospital of China Medical University, 110004, Shenyang, China;Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping, 110004, Shenyang, Liaoning, China;

关键词: Long non-coding RNA;    XIST;    Oncogene;    Cancer;   

DOI  :  10.1186/s10020-021-00421-0

来源: Springer

【 摘 要 】

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study.

【 授权许可】

CC BY