An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma

BMC Oral Health

Research

Ye Song¹  Yinting Ren¹  Jingying Han¹  Junlong Da²  Junyu Ren³ 

[1] Department of Orthodontics, The Second Affiliated Hospital of Harbin Medical University, 150001, Harbin, Heilongjiang, China;Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China;Oral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China;

关键词: Autophagy;    Long non-coding RNA;    Tongue squamous cell carcinoma;    TCGA;    Prognostic signature;   

DOI  :  10.1186/s12903-023-02806-5

 received in 2022-07-30, accepted in 2023-02-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTongue squamous cell carcinoma (TSCC) is the most common oral cancer with a poor prognosis. At present, there is not any systematic study on autophagy-related long non-coding RNA (lncRNA) to predict the survival of patients with TSCC.Material and methodsIn this research, the cohort of TSCC patients were obtained from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analysis showed that ten lncRNAs related to autophagy AC010326.3, AL160006.1, AL122010.1, AC139530.1, AC092747.4, AL139287.1, MIR503HG, AC009318.2, LINC01711, and LINC02560 are significantly correlated with prognosis. Based on these lncRNAs, a prognostic signature was established. This signature has an AUC value of 0.782, which accurately distinguishes patients of TSCC into high-risk and low-risk groups in different clinical hierarchical information (such as gender, age, etc.).ResultsThe clinical nomogram with autophagy-related lncRNA prognostic characteristics has a concordance index of 0.81, and accurately predicts the survival time at 1-year and 3-year of TSCC patients. Related functional enrichment results indicate that the pathways of the high-risk group are enriched on cancer and autophagy.ConclusionsThe autophagy-related lncRNA prognostic signature established in this study could accurately predict the prognosis of TSCC patients and may be a molecular biomarker and therapeutic target.

【 授权许可】

CC BY   
© The Author(s) 2023

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